The Cockcroft-Gault equation to calculate creatinine clearance is:
\[ \text{CrCl (mL/min)} = \frac{(140 - \text{age}) \times \text{weight (kg)} \times \text{sex factor}}{72 \times \text{serum creatinine (mg/dL)}} \]
For females, multiply the result by 0.85.
Creatinine clearance (CrCl) is a measure of kidney function. It estimates the rate at which creatinine is cleared from the blood by the kidneys, helping to assess renal function.
Consider a male patient aged 50 years, weighing 70 kg, with a serum creatinine level of 1.2 mg/dL:
Using the formula:
\[ \text{CrCl (mL/min)} = \frac{(140 - 50) \times 70 \times 1}{72 \times 1.2} = 68.06 \text{ mL/min} \]
This means the creatinine clearance is 68.06 mL/min.
