Accumulation Ratio Calculator

Formula

The formula to calculate the Accumulation Ratio (Rac) is:

\[ Rac = \frac{AUC_{ss}}{AUC_{1}} \]

Where:

\(Rac\) is the Accumulation Ratio
\(AUC_{ss}\) is the area under the curve during single dose steady state
\(AUC_{1}\) is the area under the curve during a dose interval after one single dose

Accumulation Ratio Definition

The Accumulation Ratio (Rac) is a measure used in pharmacokinetics to determine the extent to which a drug accumulates in the body after multiple doses. It is calculated by dividing the area under the curve (AUC) during single dose steady state by the AUC during a dose interval after one single dose. This ratio helps in understanding the drug's behavior and its potential for accumulation over time.

Example Calculation

Let's assume the following values:

Area Under the Curve During Single Dose Steady State (AUC_ss) = 500
Area Under the Curve During a Dose Interval After One Single Dose (AUC₁) = 250

Using the formula to calculate the Accumulation Ratio (Rac):

\[ Rac = \frac{500}{250} = 2 \]

The Accumulation Ratio (Rac) is 2.